CANTAM is the first regional network of excellence supported by EDCTP in Sub-Saharan Africa for the conduct of clinical trials on HIV/AIDS, malaria and tuberculosis in compliance with ICH/GCP standards. Four, two, one and one institutions established in Cameroon, Republic of Congo, Gabon and Germany, respectively were partners.
Aims:- Developing human resources in skills required to conduct safe clinical trials including GCP/GLP training, preparation and development of clinical and standardized protocols from recruitment of participants and treatment of biological samples.
- Strengthen ethics review boards and regulatory authorities in needy collaborating sites
- Strengthen laboratories to be able to perform relevant tests
- Establish effective community liaison at each site and to collect baseline data necessary for future interventions.
Strategy:The established institutions had the role to bring the emerging ones to a higher level through transfer of techniques, mentorship and training programs, supervision and fund raising .
The indicators of success were set on the emerging institutions.
In Cameroon and Congo, epidemiological studies for collecting data on HIV, Malaria and TB infections
(prevalence, genotypes of strains, level of resistance to drug, age-distribution,) were materialized
by 8 publications.
A total of 06 MSc and 9 PhD students were trained at the different institutions in collaboration with Northern Partners. Staff also gained skilled through short term training of lab technicians, nurses, etc.
CANTAM consolidated its collaborations with other regional and international networks by sharing knowledge and training activities.
Specific objectives:CANTAM1 had the following specific objectives in summary form:
- SO1. To develop infrastructure
- SO2. To develop Human resources
- SO3. To collect baseline data necessary for future interventions
- SO4. Networking & Fund raising
Results and outcomesSO1. To develop infrastructure:
Renovation and equipment for the following structures were
established in Cameroon and Rep of Congo.
Tuberculosis Laboratory of University of Yaoundé1
Malaria research Unit at Hospital of makélékélé , Brazzaville, Republic of Congo Molecular biology and Parasitology labs at the Fcaulty of Health Sciences, Brazzaville, Republic of Congo
Capacity buildingSO2. To develop Human resources
|Institutions||Nb of trainees||Level|
|University Yaoundé 1||7||3 Msc; 4 PhD|
|University of Buea||4||2 Msc, 2PhD|
See list of publications
- Local institutions
- Regional (EDCTP NoEs, AMANET, CAMBIN, CAEN)
- International (WWARN,DAAD,IP,ARCEAU,…)*
- Public & Private Partnership Pfizer, Malaria Clinical Trials Cameroon
- Total E&P partnership Congo
- OMS, CNLS, UNAIDS, Congo
- Felix Koukouikila-Koussounda, Francine Ntoumi, Mathieu Ndounga, Hoang V. Tong, Peter G. Kremsner, Ange-Antoine Abena, Velavan TP. Regulatory polymorphisms in the promoter region of STAT6 and FOXP3 are associated with protection against uncomplicated malaria and high Plasmodium falciparum parasitemia in Congolese children. Malaria Journal. Jan8; 12:9.
- Francine Ntoumi, Jeannhey C.Vouvoungui, Rod Ibara, Miguel Landry, Anissa Sidibé.. 2013. Malaria burden and case management in the Republic of Congo: Limited use and application of Rapid Diagnostic Tests results. BMC Public Health . Feb 14;13(1):135.
- Odile Ouwe-Missi-Oukem-Boyer, Nchangwi Syntia Munung, Francine Ntoumi, Aceme Nyika and Godfrey B. Tangwa. 2013. Capacity Building of Health Research Ethics in Central Africa: Key players, current state and recommendations. Bioethica Forum (Swiss journal of biomedical Ethics) Vol 67, n°1, 4-11
- Miiro G, Ouwe Missi Oukem-Boyer O, Sarr O, Rahmani M, Ntoumi F, Dheda K, Pym A, Mboup S, Kaleebu P . 2013. EDCTP Regional Networks of Excellence: unprecedented changes in the landscape of clinical trials in Africa. BMC Public Health Mar 22;13:258. doi: 10.1186/1471-2458-13-258.
- Felix Koukouikila-Koussounda, Ange-Antoine Abena, August Nzoungani, Jean-Vivien Mombouli, Jean-Maurille Ouamba, Jürgen Kun, Francine Ntoumi . 2013. In vitro evaluation of antiplasmodial activity of extracts of Acanthospermum hispidum DC (Asteraceae) and Ficus thonningii Blume (Moraceae), two plants used in traditional medicine in the Republic of Congo. African Journal of Traditional, Complementary and Alternative Medicines . Volume 10, No. 2, 2013. pp.270-276.
- Larissa Kamgue Sidze, Emmanuel Mouafo Tekwu, Christopher Kuaban, Jean-Paul Assam Assam, Jean-Claude Tedom, Stefan Niemann, Matthias Frank, Véronique n. Penlap Beng . Estimates of genetic variability of mycobacterium tuberculosis complex and its association with drug resistance in Cameroon. Advance Infectious Diseases, Vol.3 No.1, March 2013.
- Ndounga M, Mayengue PI, Casimiro PN, Loumouamou D, Basco LK, Ntoumi F, Brasseur P. Artesunate-amodiaquine efficacy in Congolese children with acute uncomplicated falciparum malaria in Brazzaville. Malaria Journal. 2013 Feb 5;12:53. doi: 10.1186/1475-2875-12-53.
- Williams JR, Sprumont D, Hirtle M, Adebamowo C, Braunschweiger P, Bull S, Burri C, Czarkowski M, Fan CT, Franck C, Gefenas E, Geissbuhler A, Klingmann I, Kouyaté B, Kraehenbhul JP, Kruger M, Moodley K, Ntoumi F, Nyirenda T, Pym A, Silverman H, Tenorio S. 2013. Consensus standards for introductory e-learning courses in human participants research ethics. J Med Ethics. Aug 19. doi: 10.1136/medethics-2013-101572
- Airy Barrière Yetgang Fodjo 1,2*, Jude Daiga Bigoga 1,2, John Tamoh Nguasong 1, Arnaud Djou Kaze 1, Raymond Tabue 1, Vitalis Suh Otia 1, Philomina Nyonglema1, Christiane Minka Minka3, Roger Somo Moyou 3,4, Rose Gana Fomban Leke 1,4 (Under review; Plos One) Malaria prevalence in the rubber cultivated area of niete, south region of Cameroon (2013).
With the successes of CANTAM1, we however faced challenges and gaps in HIV and Tuberculosis.
In CANTAM2, it is important to participate in common interventions and synergize for instance on the number of patients that could be enrolled as a consortium.
In order to increase HIV and Tuberculosis expertise, it is necessary to expand the network and invite new partners with a Tuberculosis/HIV expertise, emerging and re-emerging diseases with TB Host directed therapies.
Face with these challenges, we were awarded the opportunity to venture CANTAM2.
In order to improve communication with stakeholders and communities, CANTAM2 coordination team has to be strengthened by a communication officer.
In collaboration with project managers, they will elaborate a new website; new communications supports and improve intra network communication.